Doctorial Thesis Regulation of Branched-Chain Amino Acid Catabolism
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چکیده
........................................................................................................... 1 Abbreviations ................................................................................................... 3 Chapter 1 General introduction ........................................................................ 3 1. The importance of branched chain amino acids ....................................... 5 2. Catabolism of BCAAs ............................................................................... 7 3. System L amino acid transporter .............................................................. 9 4. Mammalian target of rapamycin (mTOR) ................................................ 11 5. Aim of this thesis research ...................................................................... 13 Chapter 2 Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter .................................................................... 14
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Regulation of branched-chain amino acid catabolism.
Catabolism of the branched-chain amino acids is regulated in part at the step catalyzed by the branched-chain alpha-ketoacid dehydrogenase complex. Previous work suggests both short-term and long-term control mechanisms are involved in regulation of the kinase responsible for phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex. Recent work of this laborat...
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